Trial by Battle

The BATTLE trial: personalizing therapy for lung cancer.

UNLABELLED The Biomarker-integrated Approaches of Targeted Therapy for Lung Cancer Elimination (BATTLE) trial represents the first completed prospective, biopsy-mandated, biomarker-based, adaptively randomized study in 255 pretreated lung cancer patients. Following an initial equal randomization period, chemorefractory non-small cell lung cancer (NSCLC) patients were adaptively randomized to er...

The BATTLE Trial : Personalizing Therapy for Lung Cancer Cancer

Edward S. Kim*, Roy S. Herbst*, Ignacio I. Wistuba*, J. Jack Lee*, George R. Blumenschein Jr, Anne Tsao, David J. Stewart, Marshall E. Hicks, Jeremy Erasmus Jr, Sanjay Gupta, Christine M. Alden, Suyu Liu, Ximing Tang, Fadlo R. Khuri, Hai T. Tran, Bruce E. Johnson, John V. Heymach, Li Mao, Frank Fossella, Merrill S. Kies, Vassiliki Papadimitrakopoulou, Suzanne E. Davis, Scott M. Lippman1,†, and ...

Natriuretic peptide-guided therapy for heart failure: ready for "battle" or too "scarred" by the challenges of trial design?

The last battle.

When Australian soldiers returned from World War I they were of ered the chance to settle on ‘land i t for heroes’. Promotional material painted a picture of prosperous farms and contented families, appealing to returned servicepeople and their families hoping for a fresh start. Yet just 20 years after the inception of these soldier settlement schemes, fewer than half of the settlers remained o...

Arctic battle deepens

Researchers were hoping the dramatic melting of Arctic ice recorded last year may have been exceptional, but the latest evidence suggests that this year's summer melting has been equally dramatic, with some scientists now predicting that the Arctic may be ice-free in the summer in as little as five year's time. While there has been much hand-wringing about the ecological consequences of such de...